By Perkin G David

ISBN-10: 1850709432

ISBN-13: 9781850709435

Any dialogue of the scientific features of Parkinson's ailment needs to take into consideration the inaccuracies of medical prognosis. In a successive sequence of a hundred sufferers with a medical analysis of Parkinson's illness, basically seventy six fulfilled the factors for prognosis at autopsy exam. makes an attempt to tighten the diagnostic standards result in elevated specificity yet with lowered sensitivity.In An Atlas of Parkinson's sickness and similar issues Dr. David Perkin has compiled a sequence of pictures highlighting a number of facets of Parkinson's affliction and similar motor problems. The booklet presents an invaluable pattern of medical, investigative (CT, MRI, and puppy) and pathological photographs with succinct descriptive textual content of the problems featured. nearly one-third of the fabric during this booklet is pathological, incorporating either macroscopic and microscopic sections. another region of the cloth is represented via imaging, largely magnetic resonance imaging (MRI) and positron emission tomography (PET) scanning. the realm of stream problems has been rather fruitful for puppy scanning, which gives you, with the improvement of particular ligands for a few of the receptor websites, to additional extend figuring out of the pathophysiological mechanisms of the move problems. Reflecting the top criteria scientific images and imaging besides the celebrated author's professional wisdom of the topic, Dr. Perkin's An Atlas of Parkinson's disorder and similar problems is the definitive and crucial medical reference in its box.

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Extra info for An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series)

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Persistent blinking is a feature of Parkinson’s disease, but is also seen in Alzheimer’s disease Figure 15 6-[18F]-fluorodopa–PET scan appearance in a normal subject (upper) compared with a Parkinsonian patient (lower) ©2004 CRC Press LLC Nerve terminal + Levodopa 3,4-Dihydroxyphenylacetic acid Selegiline Levodopa dopa decarboxylase – monoamine oxidase-B Dopamine Amantadine + Glial cell Homovanillic acid reuptake Dopamine 3-Methoxytyramine COMT – Tolcapone + Bromocriptine Lysuride Pergolide Ropinirole Cabergoline Terminal expressing either D1 or D2 receptor Postsynaptic neuron Figure 16 Synthesis and metabolism of dopamine within the central nervous system.

When asked to copy three hand postures (A–C, lower), in each instance, the patient's version was defective (A–C, upper) ©2004 CRC Press LLC Figure 50 In this patient with corticobasal degeneration, sagittal T1-weighted MRI (upper) shows predominantly posterior frontal and parietal atrophy (arrowed).

Evidence of Purkinje cell degeneration (right) with formation of axon torpedoes (white arrow) is seen in the molecular layer (H & Es) ©2004 CRC Press LLC Figure 40 Histological sections showing examples of oligodendroglial cytoplasmic inclusions in multiple system atrophy (H & Es) ©2004 CRC Press LLC Figure 41 Sagittal T1-weighted MRI showing pontine (black arrow) and cerebellar (white arrow) atrophy in a patient with olivopontocerebellar atrophy ©2004 CRC Press LLC Figure 42 T2-weighted MRI (upper) shows hyperintensity of the middle cerebellar peduncles and the cerebellum.

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An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series) by Perkin G David


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